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¡esta es la paradoja
        de los conservantes!

        
  
         

      
      
        

        
        Logo: Keratos - Revenir au site, Back to siteKeratos 
        es una organización 
        europea sin fines lucrativos ubicada legalemente en Francia, pero con 
        delegaciones o miembros en Portugal, Bélgica y Noruega sobre 
        enfermedades de la superficie ocular y disfunciones del sistema lacrimal 
        (incluyendo el ojo seco 
        / la sequedad ocular). Esta asociación de pacientes 
        regida según la ley francesa busca a proporcionar información a, y 
        mejorar las condiciones de, las víctimas de enfermedades de la 
         oculares.

      
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      Queremos agradecer las contribuiciones 
      de: Dotanne (Nueva Zelanda), Luísa
      (Portugal), Neil y Matt (EUA), Steve 
      (Canadá), Toril (Noruega). Más generalmente, este
      sitio es dedicado a todas las víctimas de 
      los conservantes oculares. Si aún 
      no está convencido por los efectos negativos de los conservantes 
      en los colirios o Usted desea aprender más sobre 
      el tema, trate de leer los siguientes estudios:
      

        
Sites:

        

        http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=3549&nbr=2775

        

        
        http://www.iovs.org/cgi/content/full/42/3/642

        

        
        http://www.iovs.org/cgi/reprint/25/12/1453.pdf

        

        
        
        http://www.knowledgeofhealth.com/blog/2001_09_01_archive.html

        

        
        
        http://www.ingentaconnect.com/content/mksg/cod/2005/00000052/00000006/art00008

        

        
        http://www.medscape.com/viewarticle/512387_4 

        

        
        
        http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16900358&query_hl=1&itool=pubmed_docsum 

        

        
        http://www.optometric.com/article.aspx?article=71748 

        

        
        http://www.eyeworld.org/article.php?sid=3583 

        

        
        http://www.dryeyezone.com/talk/showthread.php?t=2460 

        

        
        
        http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17003409&query_hl=7&itool=pubmed_docsum 

        

        
        
        http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16799018&query_hl=1&itool=pubmed_docsum 

        

        
        http://www.clspectrum.com/article.aspx?article=13025 

        

        
        http://www.aios.org/proceed2003/External/Ext11.pdf 

        

        
        http://www.medscape.com/viewarticle/512387_References 

        

        
        
        http://www.pharmcast.com/Patents100/Yr2005/Sept2005/092705/6949241_Eye092705.htm 

        

        
        
        http://www.chinadaily.com.cn/english/doc/2005-08/04/content_466206.htm 

        

        
        http://www.iovs.org/cgi/content/abstract/47/7/2812 

        

        
        
        http://www.revoptom.com/index.asp?ArticleType=SiteSpec&page=osc/feb01/lesson_0201.htm

        

        
        
        http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17172885&query_hl=13&itool=pubmed_docsum

        

        
        
        http://www.ingentaconnect.com/content/tandf/orbi/1999/00000018/00000002/art00003?crawler=true

        

        http://dev.expertsmtl.com/cme4/mediconcept/Noecker.pdf

        

        
        
        http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=7742279

        

        
        
        http://www.ophmanagement.com/article.aspx?article=86656

        
Etudes:

        

        Graefes 
        Archive for Clinical Experimental Ophthalmology. 2006 Aug 10;
        Comparative study of topical anti-allergic eye drops on human 
        conjunctiva-derived cells: responses to histamine and IFNgamma and 
        toxicological profiles. Pauly A, Brignole-Baudouin F, Guenoun JM, 
        Riancho L, Rat P, Warnet JM, Baudouin C. U598, INSERM, Cordeliers 
        Biomedical Institute, 15 rue de l'ecole de medecine, 75006, Paris, 
        France.

        

        Prevalence of ocular 
        symptoms and signs with preserved and preservative free glaucoma 
        medication. Pisella PJ, Pouliquen 
        P, Baudouin C.APHP Ambroise Pare Hospital, University Paris V, 
        Ophthalmology Department, 9, avenue Charles de Gaulle, 92100 Boulogne, 
        France.

        

         A 
        comparative study of the ocular tolerance after administration of 
        anti-allergic eye drops with or without a preservative
        [Article in 
        French] Beden C, Helleboid L, Marmouz F, Liard F. Societe Naxis, Lyon, 
        France.

        

        Comparison of the 
        Short-Term Effects on the Human Corneal Surface of Topical Timolol 
        Maleate With and Without Benzalkonium Chloride. Journal of Glaucoma. 
        12(6):486-490, December 2003. Ishibashi, Takeshi MD; Yokoi, Norihiko MD, 
        PhD; Kinoshita, Shigeru MD, PhD.

        

        Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man. 
        WS Wilson, AJ Duncan and JL Jay. 1975 by the British Journal of Ophthalmology.

        

        Preservative-free artificial tear preparations. 
        Assessment of corneal epithelial toxic effects . G. J. Berdy, M. B. 
        Abelson, L. M. Smith and M. A. George. Eye Research Institute, 
        Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.
        

        

        Corneal toxicity 
        secondary to inadvertent use of benzalkonium chloride preserved viscoelastic material in cataract surgery. 
        Eleftheriadis et al.
        Br. J. Ophthalmol. 2002;86:299-305.

        

        Allergy and preservatives. Apropos of 3 cases of allergy 
        to benzalkonium chloride
        
        Chiambaretta F,
        
        Pouliquen P,
        
        Rigal D. Service d'Ophtalmologie, 
        Hopital Gabriel-Montpied, CHRU, Clermont-Ferrand: J Fr Ophtalmol. 
        1997;20(1):8-16

        

        Solving the Preservative Paradox. Better packaging for nonpreserved tears is the answer. BY HERBERT L. 
        GOULD M.D., F.A.C.S.

        

        Prevalence of ocular symptoms and signs with preserved 
        and preservative free glaucoma medication.P 
        J Pisella1,2, P Pouliquen3 and C Baudouin1,4 
        .1 APHP Ambroise Paré Hospital, University 
        Paris V, Ophthalmology Department, 9, avenue Charles de Gaulle, 92100 Boulogne, France. 
        2 
        Bretonneau University Hospital, Ophthalmology Department, 2, boulevard 
        Tonnellé, 37044 Tours Cedex 1, France. 3 Théa Laboratories, 
        12, rue Louis-Blériot, - ZI du Brézet, 63017 Clermont-Ferrand, Cedex 2, 
        France,4 XV-XX National Hospital, University Paris V, 28, rue de 
        Charenton, 75012 Paris, France 

        

        Br J Ophthalmol 1998;82:39-42 
        ( January )Short term comparative study of topical 2% carteolol with and 
        without benzalkonium chloride in healthy volunteers
        Christophe Baudouin,a
        Christine de Lunardob 
        Br J Ophthalmol 1998;82:39-42 ( January )

        

        Short term comparative study of topical 2% carteolol with and 
        without benzalkonium chloride in healthy volunteers.
        Christophe Baudouin,a
        Christine de Lunardob
        a Department of Ophthalmology, Ambroise Paré, 
        University of Paris-V René Descartes, France, b Center 
        of Clinical Pharmacology, Pasteur Hospital, University of Nice, Francea Department 
        of Ophthalmology, Ambroise Paré, University of Paris-V René Descartes, 
        France, b Center of Clinical Pharmacology, 
        Pasteur Hospital, University of Nice, France

        

        Quaternary Ammoniums and Other 
        Preservatives’ Contribution in Oxidative Stress and Apoptosis on Chang 
        Conjunctival Cells 
        Caroline Debbasch1,2, 
        Françoise Brignole3, Pierre-Jean Pisella1,2, 
        Jean-Michel Warnet1, Patrice Rat1 and Christophe 
        Baudouin2 
        1 From the Unit of Cellular Pharmacotoxicology, Centre 
        Hospitalier National d’Ophtalmologie des Quinze-Vingts, the Toxicology 
        Laboratory, University of Paris-V; and the 2 Ophthalmology 
        and 3 Immunohematology Services, Hôpital Ambroise Paré, 
        Assistance Publique–Hôpitaux de Paris, University of Paris-V, Boulogne, 
        France. 

        
Impact 
        of short-term exposure of commercial eyedrops preserved with 
        benzalkonium chloride on precorneal mucin, So-Hyang Chung,1 Su Kyung 
        Lee,1 Stephen M. Cristol,2 Eun Suk Lee,3 Dong Wook Lee,4 Kyoung Yul 
        Seo,1 Eung Kweon Kim1,5.

        
Cha SH, 
        Lee JS, Oum BS, Kim CD. Corneal epithelial cellular dysfunction from 
        benzalkonium chloride (BAC) in vitro. Clin Experiment Ophthalmol 
        2004;32(2):180-4.

        

        RegeneRx's TB4 Subject of Four Presentations at 2005 ARVO Meeting; 
        Researchers Present New Data Indicating TB4 May Reduce Deleterious 
        Effects Associated with Chronic Use of Eye Drops, Business Wire, May 2, 
        2005.

        

        Investigative Ophthalmology and Visual Science. 2006 Jul; 47(7):2812-9. Fluoroquinolone eye drop-induced cytotoxicity: role of preservative in 
        P2X7 cell death receptor activation and apoptosis.* 
        Dutot M,* Pouzaud F, * Larosche I,* 
        Brignole-Baudouin F,* Warnet JM,* Rat P.Laboratoire de Toxicologie, 
        Faculte des Sciences Pharmaceutiques et Biologiques, Université Rene 
        Descartes-Paris, and Centre Hospitalier National d'Ophtalmologie des 
        Quinze-Vingts, Paris, France.

        
  
        Mientras tanto, por favor, 
        trate de leer la parte restante del sitio web en francés
        
      
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